Complexity in Transcription Control at the Activation Domain-Mediator Interface
نویسندگان
چکیده
منابع مشابه
Complexity in transcription control at the activation domain-mediator interface.
Transcript elongation by polymerase II paused at the Egr1 promoter is activated by mitogen-activated protein kinase phosphorylation of the ternary complex factor (TCF) ELK1 bound at multiple upstream sites and subsequent phospho-ELK1 interaction with mediator through the MED23 subunit. Consequently, Med23 knockout (KO) nearly eliminates Egr1 (early growth response factor 1) transcription in emb...
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ژورنال
عنوان ژورنال: Science Signaling
سال: 2009
ISSN: 1937-9145
DOI: 10.1126/scisignal.1164302